Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation
The DNA helicase RECQL4 is Decking Oil known for its roles in DNA replication and repair.RECQL4 mutations cause several genetic disorders including Rothmund-Thomson syndrome (RTS), characterized by developmental defects and predisposition to osteosarcoma.Here we reprogrammed fibroblasts with a heterozygous RECQL4 mutation (c.1878 + 32_1878 + 55del2